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These two seem to go hand in hand so if you deal with one of them the other has a reciprocal reaction

The foundational characterization is Lee et al., Cell Metabolism, 2015 (PMID 25738459) [1]

While ERRs are not the canonical thermogenic receptors like PPARs or -adrenergic receptors, their downstream gene networks overlap with brown/brite adipocyte mitochondrial machinery, offering one route for increased energy dissipation under SLU-PP-332 exposure

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Side effects of certain medications such as antidepressants, anti-nausea drugs, and allergy medicines, especially older antihistamines, can aggravate or worsen symptoms of restless legs syndrome