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Vitamin D can be made in the skin (upon exposure to ultraviolet B [UVB] radiation from the sun) and obtained from dietary and supplemental sources

While translational gaps persist, particularly in dosing, timing, and patient stratification, emerging strategies including mitochondria-targeted antioxidants, nanotherapeutics, and biomarker-guided interventions hold promise for restoring redox homeostasis and improving clinical outcomes

Furthermore, one of the most important brain metabolic markers is N-acetyl-aspartate (NAA) which contributes to the production of energy by the mitochondria

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The generation of highly reactive ROS is an important feature of the normal cellular system such as fertilization, ovulation, arachidonic acid metabolism, phagocytosis, and mitochondrial respiratory chain