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Nutrients 10:1614

The assay was performed both in the presence and absence of metabolic activation (S9 fraction)

This is important in laboratory studies, as LPS can interfere with experimental outcomes and immune-response measurements in research models

Recognition and lysis of altered-self cells by macrophages

Inhibition of glutamine metabolism has been confirmed to be promising in glutamine-addicted cancer cells, including glutamine analogs like DON, acivicin, and azaserine, glutamine transporter inhibitor GPNA and V-9302, GLS1/2 inhibitors (Shen et al., 2021)