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141,142 Thus, a number of authors have examined the possibility that metformin might be the cause of a vitamin B 12 deficiency and subsequently directly responsible for peripheral neuropathy in T2DM patients

Nipper AJ, Smithey MJ, Shah RC, Canaday DH, Landay AL

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KO increased the expression of anti-inflammatory cytokine IL-10 and decreased pro-inflammatory cytokine IL-1

Given the strong association between glutathione depletion and the progression of mitochondrial diseases, dietary supplements with the potential to increase intracellular glutathione reserves have been the subject of much research in recent years [11]