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Aptamers-short, single-stranded oligonucleotides selected through systematic evolution of ligands by exponential enrichment (SELEX)-offer a powerful, flexible, and stable targeting modality ( We hypothesized that a fibrin-targeted, ROS-responsive GO nanocomposite encapsulating GSH (GO@GSH-FA) would selectively accumulate in ischemic brain regions and release its antioxidant payload in response to local oxidative stress

They were then assigned to receive 600 mg of PEA plus 500 mg of acetyl-L-carnitine twice daily in addition to medical treatment or continue medical treatment alone for another 12 weeks

Addressing these knowledge gaps through genotype-stratified trials, the inclusion of advanced disease and co-infected cohorts, and transparent TRL mapping will be key to transitioning from promising proof-of-concept to clinically adoptable and affordable therapies [209,210,211]

Bowers et al

(N = 6)