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Catalase's capacity to lower oxidative stress and inflammation shows its potential as a therapeutic agent in the treatment of CAP, which might lead to better clinical results and reduced disease severity [95, 96]

(L-N) Western blot analysis and quantitative assessment of MMP-2 and MMP-9 protein expression levels in each group

doi: 10.1111/j.1365-3040.2011.02400.x 53 OgawaK.Hatano-IwasakiA.YanagidaM.IwabuchiM

In our recent study, in addition to elucidating the pathogenic mechanism of FUS-associated ALS in both Drosophila and animal systems, we found that overexpression of GstO2, a Drosophila homolog of human GSTO1, reduces cytoplasmic FUS aggregates and attenuates neurodegenerative phenotypes, including mitochondrial dysfunction and neuronal toxicity 148

These reactive species can damage surrounding tissues and DNA, promoting mutations and genomic instability