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This review will focus on the roles of NNMT in obesity and T2D, as it has been found that the expression of this methyltransferase is elevated in the white adipose tissue and liver of obese people and diabetic mice and that NNMT knockdown protects against diet-induced obesity and insulin resistance [11]

It builds on the progress of earlier compounds like Semaglutide and Tirzepatide by activating three key hormonal pathways involved in appetite

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Obesity in the mouse model of pro-opiomelanocortin deficiency responds to peripheral melanocortin