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(1988) Selenium: geochemical distribution and associations with human heart and cancer death rates and longevity in China and the United States, Biol

The pharmacological action of disulfiram (DSF) is attributed to the inhibition of acetaldehyde metabolism by aldehyde dehydrogenase (ALDH) in the liver 2,3

Quantitative analysis confirmed that the inhibitory effect of aloe emodin is better than that of emodin, suggesting distinct mechanisms for each compound against breast cancer metastasis [503]

Activation of the farnesoid X receptor (FXR), a ligandactivated nuclear hormone receptor that is a key regulator of bile acid homeostasis, has demonstrated clinical benefit in patients with PSC, as shown by the sustained reduction in serum alkaline phosphatase levels induced by multiple FXR agonists, including obeticholic acid in a phase 2 trial (NCT02177136)

For instance, IGF-I attenuated the response of theMCF-7 BC cell line to doxorubicin and paclitaxel by at least two mechanisms: induction of proliferation and inhibition of apoptosis (Zeng et al., 2009)