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To validate the interaction between ABCC1 and Venetoclax in more detail, we established single-cell-derived MOLM-13 clones expressing ABCC1- or AAVS1 -targeting sgRNAs

Malcolm Brenner is Director of the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital, and Houston Methodist Hospital, which is responsible for the stem cell transplant programs at these institutions

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways

Future work will also incorporate functional parameters such as albumin production and ammonia tolerance as well as markers of cell redox status (reduced GSH, superoxide dismutase, catalase)