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Following hyperosmotic stress, some ribosomal proteins that failed to properly fold can undergo ubiquitination, and RAD23B, a shuttle factor that has ubiquitin-associated domains, further drives LLPS of ubiquitinated ribosomal proteins and nuclear proteasomes, leading to proteasomal removal of misfolded ribosomal proteins

Kyei NNA, Cramer B, Humpf HU et al (2022) Assessment of multiple mycotoxin exposure and its association with food consumption: a human biomonitoring study in a pregnant cohort in rural Bangladesh

Molecular and cellular research has shown that Gut dysbiosis (GD) influences PD progression by various pathways, including GBA, Toll-like receptors (TLR), Humoral immunity response (HIR), -synuclein accumulation and hypothalamicpituitaryadrenal (HPA) axis (11)

One such pathway, identified later, is the FSP1 pathway

This therapeutic resistance largely stems from GSHs strong antioxidant and detoxifying functions [17]