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16, 626638 (2016), 10.1038/nri.2016.90

Hypertension may not be effectively treated with the use of diuretics, ACE inhibitors, beta-blockers, alpha-blockers, calcium channel blockers, direct vasodilators, renin inhibitors, etc

Oscillatory positive expiratory pressure (OPEP) devices are intended to facilitate sputum clearance and reduce cough

As a result, Nrf2 is free to travel to the nucleus, where it binds to antioxidant response elements (AREs) of DNA

Furthermore, disruption of GLS1 signalling using gene depletion or the use of the Gln inhibitor CB-839 will also lead to ubiquitination of c-MYC proteins, creating a GLS1-c-MYC positive feedback loop