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3.4.4 Alkaloids: comprehensive miRNA biogenesis modulation Berberine targets multiple oncogenic miRNAs, including miR-21 (5070% reduction in HCT116 cells), miR-23a (2.5-fold increase in hepatoma cells), and suppression of the miR-1792 cluster in multiple myeloma

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doi: 10.3390/antiox12030548 92 LiJJiaYCDingYXBaiJCaoFLiF

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Larger and longer-term human studies are still needed to confirm meaningful or sustained weight-loss effects