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Description

Fundacin Instituto de Investigacin Sanitaria y Biomdica de Alicante ISABIAL (UGP-21-172UGP-20-207 and UGP-21-104)

Tentolouris A, Ntanasis-Stathopoulos I, Terpos E

Drugs 27 , 595599 (2018)

Set the vial aside and let the peptide dissolve naturally

The stapled peptide they used involved olefinic amino acid Fmoc-( S )-2-(4entenyl)-alanine bound at suitable i , i + 4 positions at the non-binding interface as the staple, and it was found that both selected stapling peptides LCIP1 and LRIP4 exhibited improved cell permeability as compared to the native one in a dose-dependent manner monitored by flow cytometry [130]