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Such fluctuations play a vital role in maintaining the 24-hour rhythm of the cells

[DOI] [PubMed] [Google Scholar] 113.Ahmad A., Shameem M., Husain Q

Acknowledgements We thank Xuewu Zhang for his comments on our paper

The increased oxidative load disrupts the bodys intrinsic antioxidant defense systems, such as manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx), leading to lipid peroxidation, DNA damage, and activation of pro-apoptotic pathways, such as p53 and BAX 5,7