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(A ) PLS-DA score plot as multivariate data analyses based on metabolomics data between three tamoxifen-treated groups (each group contains 9 samples) compared to the control group (n = 9)

However, the study showed that BDNF-TrkB signaling plays a necessary role in mediating CSDS-induced social avoidance behavior in the ventral tegmental area (VTA)-NAc, and established BDNF-TrkB signaling as a pathological mechanism during chronic stress [116]