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Thus, this epigenetic alteration is now considered as a cancer biomarker but could as well play a driving role in multistep cancer development, especially well documented in prostate cancer development

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In various cancers, the balance between DNA methylation and demethylation is disrupted, leading to impaired expression of DNMT and TET

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Iron also contributes to adaptive mechanisms in cardiac control (Ravingerov et al., 2020), but its regulatory role in iron metabolism is often overlooked