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(65) using stable isotope labeling of glutamine and glucose followed by metabolomics, reported that M1 macrophages preferentially utilize glutamine, and the chemical or genetic ablation of glutamine synthase perturbs M1 polarization of the macrophages

Given the significant impact of sirtuins on energy metabolism, the development of sirtuin modulators is considered a promising avenue for drug discovery to address unmet needs in both common and rare diseases