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Collectively, these findings suggest GLP-1RAs may serve as dual-purpose agents by targeting both metabolic and inflammatory components of asthma by modulating arginine metabolism, reducing oxidative stress, preserving lung epithelial integrity, and counteracting inflammation-driven lung injury, with potential mechanistic insight shown in Fig

Inflammatory regulator genes (e.g., IL-1 and IL-6 ): primarily linked to inflammasome hyperactivation (Kawaguchi et al., 2021