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Nairz, Iron in the tumor microenvironment-connecting the dots

Future studies, including molecular profiling, may be needed to determine which patients may be the best candidates for multiple SRS courses

Depending on concentration, transition-metal availability, oxygen tension, and enzymatic context, polyphenols can generate semiquinones, quinones, hydrogen peroxide, or glutathione-consuming intermediates that shift a system from cytoprotection toward oxidative damage (Vrankova et al., 2026)