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Nat Genet (2011) 43(5):4426

& Sensb, L

Platycodin D regulates high glucose-induced ferroptosis of HK-2 cells through glutathione peroxidase 4 (GPX4)

Moreover, the urinary excretion of isoprostane, a product of the nonenzymatic oxidation of arachidonic acid, and a marker of oxidative stress, was increased in vehicle-treated D 2 / mice and was almost completely normalized by etamicastat treatment (Fig