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16 It has been shown that influenza viruses induce oxidative stress mediated by an excess of ROS and a decrease of reduced glutathione, and that such conditions favour viral replication, with glutathione depletion pivotal for the folding and maturation of the viral glycoprotein and therefore viral replication

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Furthermore, the CTLA-4 gene placed on 2q33 is known as the second most important immunoregulatory gene in autoimmune thyroid disease

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