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LDN has the ability to reduce pro-inflammatory cytokines as it was found to be allied with a decline of plasma concentrations of transforming growth factor (TGF)- which belongs to a group of cytokines that is together called The super-family TGF-, and also responsible for regulating epithelial cell differentiation, expansion , organization, motility, and apoptosis [98]

For each included study, the following information was collected: first authors name, year of publication, country of origin, type of study (in vitro, in vivo, or clinical), characteristics of the experimental model (e.g., species, sample size), specific platelet-derived product used (PRP, PRGF, PRF, or PRPL), details of preparation protocols, route and frequency of administration, and main outcome measures

J Biol Chem 271:2431324316 Lee M, Schwab C, Yu S, McGeer E, McGeer PL (2009) Astrocytes produce the antiinflammatory and neuroprotective agent, hydrogen sulfide

Hammarstedt C

The term scatter factor was later introduced independently in 1985 by Stoker and co-workers, as they discovered a protein interrupting the intracellular junctions of epithelial cells thereby promoting their migration in a paracrine manner and promoting an invasive phenotype [4]