glutathione depletion bso Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Recent Advances in Glutathione Depletion-Enhanced

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Oparaugo NC, Ouyang K, Nguyen NPN, Nelson AM, Agak GW

Reported side effects Mild headache or fatigue typically transient during initial use Mild gastrointestinal discomfort reported in some oral formulation users Sleep disruption or irritability potential sign of overstimulation Theoretical safety concerns Critical note: Because Dihexa activates the HGF/c-Met pathway which promotes cellular growth and repair there is a theoretical concern that it could potentially stimulate unwanted cell proliferation in individuals with active cancer or high cancer risk

doi: 10.1016/j.canlet.2022.215604 18 HungCSLeeKLHuangWJSuFHLiangYC

The maximum estimated daily intake of BHA from personal care products in Canada is 0.060.07 mg/kg/day [106]