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Research has shown that when normal human bronchial epithelial cells are exposed to copper, it activates the expression of heat shock response genes, ubiquitin-related genes, and autophagy regulatory genes and causes degradation of proteasomes, resulting in an increase of misfolded proteins (48)

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Based on this finding, the authors recommend that all children should be considered for dietary intervention for ADHD, provided that parents can to follow a restricted elimination diet for at least 5 weeks so that its value can be determined and that close supervision is available

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