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In addition, studies with other diet-induced MASLD animal models showed downregulation of GPx mRNA expression (Li et al

239 , 240 , 241 Several underlying mechanisms have been suggested and described, for example, the decrease in lowgrade chronic inflammation, modulation of cytokine microenvironment, restoration of the antioxidant mechanisms, improvement in immune defense against pathogens, increase in telomerase length and activity, modulation of cytokine signaling, and increase in autophagyinduced mitochondrial functions

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The researchers note that many steps must be completed before any clinical translation is possible, including developing built-in off switches to safely and reliably remove or deactivate the engineered bacteria after they are no longer needed