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The present study further analyzed the difference in expression levels of ferroptosis-related DEGs with prognostic significance in breast cancer and healthy breast tissue in the HPA database and the results demonstrated that the expression levels of three genes (TFR2, ATF3 and ZFP36) were higher in tumor tissue compared with healthy tissue, which was consistent with the bioinformatics analysis results (Fig

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Furthermore, it was noted that Nrf2 activation is amplified by SIRT1 signaling 86

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