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The interactions can be expressed by small or large conformational (enthalpic) and dynamic (entropic) changes (Tsai et al

One study indicated that down-regulating the expression of the pro-apoptotic factor Bax and reducing the Bax/Bcl-2 ratio effectively mitigated degenerative lesions in dopaminergic neurons associated with PD (Yang et al., 2025)

These numbers are meaningfully higher than tirzepatide discontinuation rates and represent an important consideration for researchers planning long-term protocols

Although our previous study of D2R-DAT interaction was conducted in mouse tissues, we have confirmed the existence of D2R-DAT interaction using rat striatal tissue and that TAT-DAT NT peptide was able to disrupt the D2R-DAT interaction in this study (Fig