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In melanoma, the response to ICIs can be enhanced by using Smac mimetics which have a direct impact on immune cells such as B cells, MDSCs, DCs, and cytotoxic T cells (Michie et al., 2020)

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doi: 10.1016/j.mam.2004.02.019

thus, ID inhibits DNA synthesis, limiting cell proliferation and repair ( Iron acts as a cofactor for cytochrome complexes in the cellular respiratory chain in normal cells, facilitating oxygen reduction and energy production