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doi: 10.1016/S0027-5107(99)00004-4

However, due to the broader flexibility in acquired drug resistance, advanced therapeutic options with better efficacy need to be explored

Advances in the regulation of osteoclasts and osteoclast functions

This patient's severe hypercholesterolemia indicates massive cholesterol accumulation rather than impaired synthesis, making decreased HMG-CoA reductase activity unlikely