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The activation of this pathway results in the upregulation of adhesion molecules (such as VCAM-1 and ICAM-1), chemokines (such as MCP-1), and inflammatory mediators (such as IL-1, IL-6, IL-8, IL-18, and TNF-a), creating a pro-inflammatory microenvironment that culminates in endothelial injury and intimal thickening (Sul and Ra, 2021