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Transplantation (2014) 98:126270

After co-incubation of HMnER with NK cells, released Mn 2+ can cause NK cells to secrete more IFN- by activating the cGAS-STING pathway in NK cells

Theranostic layer-by-layer nanoparticles for simultaneous tumor detection and gene silencing, angew

This activation stimulates the expression of genes linked to antioxidant defense mechanisms, including heme oxygenase-1 (HO-1), superoxide dismutase 2 (SOD2), catalase (CAT), and glutathione peroxidase (GPX), among others ( 2.3 Cellular senescence Repeated cellular divisions, along with the consequent attrition of telomeres, are believed to significantly contribute to the aging process