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Certain cyclooxygenase (COX) enzymes, necessary for LPO, have been localized within LDs and shown to enhance angiogenesis, suggesting that elevated LD levels may play a critical role in ferroptosis resistance (72)

Lipoic acid also plays a key role in supporting detoxification capacity

These factors orchestrate a transcriptional network that coordinates the expression of nuclear genes involved in mtDNA transcription, respiratory chain assembly, and mitochondrial dynamics