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We noted that the prototypical conformational mutant R175H, which has previously been characterized as responsive to APR-246 [10], was neither significantly enriched nor depleted in the treated population (Supplementary Fig

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Thioacetamide-Induced fulminant hepatic failure induces cerebral mitochondrial dysfunction by altering the electron transport chain complexes

In this Perspective, we first introduce a comprehensive framework for biomarkers applicable in clinical settings and discuss the existing repertoire of biomarkers used in practice