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The mass effect of the hematoma significantly increases intracranial pressure, compressing surrounding brain tissue and neural tracts, potentially leading to brain herniation (Wilkinson et al., 2018)

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For example, the excessive activation of ferritinophagy, lipophagy, clock autophagy, and CMA can promote ferroptosis by degrading iron proteins, lipid droplets, circadian rhythm regulators, and GPX4, respectively (Honma et al., 2023

But what happens to all of that extracellular glutathione

Hedman CA, Frystyk J, Lindstrm T et al (2004) Residual beta-cell function more than glycemic control determines abnormalities of the insulin-like growth factor system in type 1 diabetes