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Preclinical research indicates it remains structurally intact in acidic and enzymatic environments, making it a reliable subject for degradation and interaction studies

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Still, side effects from B12 supplements are possible, especially at higher doses, and include: Headache Nausea Vomiting Fatigue Weakness Diarrhea Tingling in the hands and feet Nasal spray Vitamin B12 is also available in a nasal spray