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10.1016/j.cell.2019.03.018 Cell

Smith LJ, Shamsuddin M, Sporn PH, Denenberg M, Anderson J: Reduced superoxide dismutase in lung cells of patients with asthma

For instance, Casgevy, based on the CRISPR/Cas9 gene-editing system, was the first successful attempt at disease treatment, promising a one-time treatment for a lifelong effect. However, the complexity of clinical applications and the difficulty of target selection in gene editing have led to long treatment cycles and high costs