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In November 2023, the FDA added BPC-157 to its list of substances that cannot be used in compounding under the Federal Food, Drug, and Cosmetic Act, citing insufficient safety data for human use 3

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The combination of a CDK4/6 inhibitor and an exportin 1 inhibitor can synergistically induce senescence in hepatocellular carcinoma cells, and the senolytic drug ARV-825 can effectively eliminate these senescent tumor cells