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Particular emphasis is placed on the gut-brain axis, mitochondrial function, and epigenetic regulation as critical pathways through which nutrition impacts mental health

For example, curcumin has been evaluated in Phase II clinical studies in pancreatic cancer and colorectal cancer patients, where oral doses up to 8 g/day demonstrated acceptable safety but limited systemic exposure, highlighting pharmacokinetic challenges

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Histopathology Four sections of 5 m were sliced from the paraffin-embedded stomach tissue