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Due to stress in the dividing cell, an imbalance in the cellular redox status causes cell proliferation and progression obstruction by controlling the CYCs and CDKs

Nature 600 , 314318 (2021)

B.Zimeo-MoraisG

The PINK1/Parkin pathway is the most extensively studied mechanism of mitophagy, and comprises three main components: PINK1 as the mitochondrial damage sensor, Parkin as the signal amplifier and ubiquitin chains as the signal effectors (39)