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Description

Loss of NCOA4 substantially decreases ferroptosis susceptibility, reducing cell death by approximately 62% (Savo and Dill, 2019)

Even so, detection still depends heavily on the type of test being used

In the absence of reduced glutathione (e.g., due to G6PD deficiency), RBCs become susceptible to oxidative stress that can damage erythrocyte membranes, resulting in intravascular and extravascular hemolysis