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After three months of HFD feeding, magnetic resonance imaging (MRI) analysis revealed that Gpr146 / male mice had significant less fat mass than wild type controls (Fig

[0232] Embodiment 225: The method according to any one of embodiments 213- 224, wherein said cancer comprises cells of a cancer selected from the group consisting of mesothelioma, testicular cancer, endometrial cancer, and ovarian, pancreatic, and non small cell lung cancers that express ALPP and/or ALPPL2

(2019) Postoperative thyroid-stimulating hormone levels did not affect recurrence after thyroid lobectomy in patients with papillary thyroid cancer

Cell 18 , 29602969 (2007)

Considering that OLFM4 can bind pan-cadherin 35 and that FAT1 is a nonclassical cadherin protein which previously identified as a key upstream regulator of the Hippo pathway 28,55 , we speculated that OLFM4 may regulate the activity of upstream Hippo signaling through FAT1