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The precursor form of BDNF, pro-BDNF interacts with a specific receptor called p75 neurotrophin receptor (p75NTR), forming the pro-BDNF/p75NTR/sortilin complex

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This degradation, in turn, allows NF-B activity to increase, resulting in increased transcription of pro-inflammatory genes, including TNF-, IL-1, IL-6, and inducible nitric oxide synthase (iNOS) (Morgan and Liu, 2011)

In short, excimer appears effective at reducing PASI scores in the studies available, but the small number of trials, wide heterogeneity and limited sample sizes temper confidence in how broadly the result applies

Oncogene (1998) 17(6):76980