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In males, GPx5 is prominent in the epididymis, where it detoxifies peroxides to protect sperm during maturation and storage

Autophagy deficiency exacerbates iron overload induced reactive oxygen species production and apoptotic cell death in skeletal muscle cells

Rosen ED, Hsu CH, Wang X, Sakai S, Freeman MW, Gonzalez FJ, et al

The role of signaling pathways such as the PI3K/AKT/mTOR and MAPK pathways in mediating the effects of iron overload on mitochondrial function has also been explored

Purification of HaloTag Fusion Proteins HaloTag Protein Purification from Mammalian Cells Cultured mammalian cells offer an environment well suited for producing properly folded and functional mammalian proteins with appropriate post-translational modifications