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Start with a low dose to assess the impact and any adverse events

These clocks are governed by transcription-translation feedback loops that produce rhythmic oscillations in gene expression, including key regulators such as PERIOD and CRYPTOCHROME

[DOI] [PubMed] [Google Scholar] Nef S, Verma-Kurvari S, Merenmies J, Vassalli JD, Efstratiadis A, Accili D, Parada LF

Finally, receptor-occupancy characterization in human tissue at clinically relevant exposures remains an open frontier that will likely be addressed in future publications

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