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If the initial oxidative enzymes are overactive due to genetic variation, or if they are upregulated by a cytochrome inducer like chronic alcohol use or certain anticonvulsants, the production of toxic metabolites can overwhelm the conjugation capacity

British Journal of Cancer, 2001, 84(11):1544-1550 The Effect of Alternating Magnetic Field Exposure and Vitamin C on Cancer Cells

Unlike MeHg, DMeHg has little electrophilicity for modifying protein thiols but shows high and delayed toxicity 7,8

Importantly, this junction also represents the entry point into the pentose phosphate pathway (PPP), which shunts glucose away from energy production and instead generates NADPH, an essential cofactor required for glutathione synthesis and redox homeostasis

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