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Larger, randomized controlled trials (RCTs) with longer follow-up periods are necessary to evaluate the efficacy and safety of topical glutathione more robustly

61-63 Treatment with gamma-glutamylcysteine ethyl ester can increase intracellular reduced GSH concentrations, and has been shown to result in a dose-dependent reduction in infarct size in a canine model of occlusion-reperfusion

Therefore, the beneficial effects of active compounds on the dermis and fibroblasts, combined with their impact on epidermal turnover (see Sect

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