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Xanthine oxidase (XO), which participates in purine metabolism, is another key enzymatic source of ROS, producing both superoxide and HO during the conversion of hypoxanthine to xanthine and xanthine to uric acid 50

However, in neutrophils treated with R848 for 6 h, PU.1 was recruited to the 27 and 4 kb regions (primers #3 and #5), at amounts comparable to monocytes (Fig