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Vandael D, Gounko NV (2019) Corticotropin releasing factor-binding protein (CRF-BP) as a potential new therapeutic target in Alzheimers disease and stress disorders

Water molecules were subsequently removed from the 3D files of receptor molecules prior to docking and then later on hydrogen atoms were added to all the target proteins

Unfortunately, several treatments, though successful in pre-clinical experimental autoimmune encephalitis trials, were either less effective in patients, worsened disease or caused unexpected, severe adverse events, as reviewed (60)

The success of such an undertaking depends, however, on a few particular, both practical and theoretical, considerations

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