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The authors concluded that GHK acts by affecting TGF-1/Smad 2/3 and IGF-1 pathway

Protein kinase B (Akt), a physiological regulator of cell growth and survival, also plays an important role in downstream insulin signaling and glucose uptake

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Beyond simple budding, LD size expansion may also be explained by biophysical models such as coalescence and Ostwald ripening, which have been proposed to contribute to LD enlargement in certain cellular settings (Fig