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2002 Jul;50(7):941-59

Cognitive and emotional disturbances are also common early indicators, manifesting as memory problems, mood swings, irritability, and nervousness

Abstract : This is a report of the reversal of two cases of scleroderma, the first case that of a fifty year old white female with severe kidney involvement, treated with intravenous EDTA and DMSO therapy, and Metranidazole and Allopurinol tablets (according to the Rheumatoid Disease Foundation protocol)